Serious allergic reactions in children are falling as new guidelines roll out

The rate of increase in serious allergic reactions to food among children has flattened since changes to the Australian infant feeding guidelines, a new study has found.

 

Under the changes, which came into effect in 2016, the recommendation was to introduce  allergenic foods such as eggs and nuts early and often – a departure from the previous approach which encouraged the avoidance of allergenic foods, or delaying their introduction until much later in a child’s life. 

 

Australasian Society of Clinical Immunology and Allergy (ASCIA) infant feeding and food allergy prevention guidelines changed in response to published studies over the past 15 years, from a recommendation to ‘delay’ allergenic foods (1999 to 2007) to ‘not delay’ (2008) and then later to ‘introduce early and often’ (since 2016).

 

In the 1990s most guidelines recommended avoiding allergenic foods until age 1-3 years and avoidance of these foods in infancy became widespread. By 2008, this advice was removed in Australia and New Zealand based on increasing evidence that delaying allergenic foods had been associated with an increased food allergy risk. 

 

Hospital admissions now stable

The research, led by the Murdoch Children’s Research Institute (MCRI) and the John James Medical Centre and published in The Journal of Allergy and Clinical Immunology, stated the rising rates of hospital admissions for food anaphylaxis (serious allergic reactions) had stabilised in young children and teenagers in Australia since 2008.

 

“Before 2008, we saw large year-on-year increases in admission rates, a bit like compound interest. But now we are seeing a flattening of the curve,” Dr Raymond Mullins from the John James Medical Centre explained.

 

“In children, aged one to four years, the yearly rate of increase dropped from 17.6 per cent a year between 1999 to 2007, to 6.2 per cent a year between 2008 to 2015 and then 3.9 per cent a year since 2016.”

 

“Whilst we did see a spike in children aged less than one year, this is most likely due to earlier hospital presentations of pre-existing food allergy following introduction of allergenic solids in the first year of life,” he added.

 

“A slowing in the rates of increase in food anaphylaxis admissions also occurred in those aged 5-14 years, born after the 2008 changes. These changes were not seen in older teens aged 15 and over who were born before 2008, who could not have benefited from the changing guidelines.”

 

The study examined national hospital admissions data for food anaphylaxis during three different time periods from 1998-1999 and 2006-2007, between 2007-2008 and 2014-2015 and between 2015-2016 and 2018-2019. A total of 37,132 anaphylaxis admissions were recorded over the timespan.

 

Professor warns against complacency 

 

MCRI Professor Mimi Tang said the study was the first real-world evidence to show that updates to allergy prevention and infant feeding guidelines were having a measurable impact on the population prevalence of food anaphylaxis, adding that despite the findings, it was important to remain vigilant to the dangers of allergy. 

 

Overall food anaphylaxis hospital admission rates had still increased and there was an unmet need for effective treatments that could induce remission, she said.

 

“The absence of an absolute drop in anaphylaxis admissions is disappointing, although it is possible that other environmental factors such as microbial exposures, diet and vitamin D levels may be driving the increased admission rates.” 

 

“It’s a positive sign that changes to Australasian guidelines have led to earlier introduction of common allergy-causing foods and that most parents have access to reliable advice. But even if early introduction of common allergy-causing foods partially reduces the risk of food allergy development, there will still be children who develop food allergy and many children and adults already have food allergy, so we need to also work towards finding effective treatments.”

 

Resources to support the safe introduction of allergenic foods to children are available through Allergy & Anaphylaxis Australia and may be accessed here. The study, Changes in Australian food anaphylaxis admission rates following introduction of updated allergy prevention guidelines, may be accessed here.